Riemannian Metric Learning for Alignment of Spatial Multiomics
ISMB 2026
Research Interests
My interests are primarily in optimal transport, including algorithmic approaches for discrete optimal transport (algorithms for primal and low-rank optimal transport), the theory of optimal transport based continuous optimization (the JKO Scheme and Wasserstein gradient flow), and computational approaches for optimization in Wasserstein space (flow-based models, score-matching). I also adapt these techniques for quantitative and computational biology, where I develop methods to infer large-scale maps and developmental trajectories in temporal single-cell and spatial transcriptomics with the goal of understanding the dynamics of cell differentiation and growth in space and time.
Publications
Multimodal spatial alignment and morphology mapping with MOSAICField
RECOMB 2026
Hierarchical Refinement: Optimal Transport to Infinity and Beyond
ICML 2025 (Oral)
Learning Latent Trajectories in Developmental Time Series with Hidden-Markov Optimal Transport
RECOMB 2025
Low-Rank Optimal Transport through Factor Relaxation with Latent Coupling
NeurIPS 2024
DeST-OT: Alignment of Spatiotemporal Transcriptomics Data
Cell Systems 2025 · RECOMB 2024
Pooled RNA-IP approach to investigate variant effects on RBP binding and splicing
ASHG 2022 (Poster)
Preprints
Talks
A selection of recent talks. Slides are linked when available.
Optimal Transport Modeling of Cellular Differentiation: From Low-Rank Structure to Temporal Dynamics
Hierarchical Refinement: Optimal Transport to Infinity and Beyond
Hidden-Markov Optimal Transport for Developmental Time Series
Low-Rank Optimal Transport through Factor Relaxation with Latent Coupling
Previous Research Projects
As an undergraduate, I worked at Foundation Medicine, supervised by Justin Newberg, Garrett Frampton, and Megan Montesion. I contributed to two projects accepted to AACR 2020:
- Pan-chromosome analysis does not reveal parental or ancestral bias in chromosome loss of heterozygosity
- Pan-cancer analysis of sex differences and their associations with ancestry and genomic biomarkers in a large comprehensive genomic profiling dataset
Teaching
I was previously a teaching assistant for Organic Chemistry at Columbia University with Professor Talha Siddiqui. I also teach Computer Science at the King Summer Institute, where I've taught an introductory Java course.
Other
Outside of my academic interests, I am an avid hiker and an amateur birder, botanist, and photographer.